Anti-CD59 Monoclonal Antibody (10H9)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price	Availability
ASPC356	Anti-CD59 Antibody (10H9)	Mouse IgG2b, Kappa		None	$460	4-6 weeks	Add
ASPC356-1	Anti-CD59 Antibody (10H9), Fab fragment	Mouse Fab	His tag	None	$460	In stock	Add
ASPC356-P	Anti-CD59 Antibody (10H9), PE	Mouse IgG2b, Kappa		PE	$1,180	4-6 weeks	Add
ASPC356-A	Anti-CD59 Antibody (10H9), APC	Mouse IgG2b, Kappa		APC	$980	4-6 weeks	Add
ASPC356-H	Anti-CD59 Antibody (10H9), HRP	Mouse IgG2b, Kappa		HRP	$600	4-6 weeks	Add
ASPC356-B	Anti-CD59 Antibody (10H9), Biotin	Mouse IgG2b, Kappa		Biotin	$680	4-6 weeks	Add

Anti-CD59 Monoclonal Antibody (10H9)
- Product Description:
  
  The Anti-CD59 antibody is a mouse monoclonal antibody recommended for use in flow cytometry, ELISA and other applications. This antibody specifically targets CD59 and demonstrates reactivity with human.
  
  Applications:
  
  Flow Cytometry, Enzyme-Linked Immunosorbent Assay
  
  Target:
  
  CD59
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human CD59 (cluster of differentiation 59).
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  10H9
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CD59 Monoclonal Antibody (10H9) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CD59

Protein Name

CD59 glycoprotein

Introduction

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Alternative Names

1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20; C59

Gene ID

966

UniProt

P13987

Molecule Mass

CD Molecules

Related Disease

Hemolytic anemia, CD59-mediated, with or without polyneuropathy (HACD59)

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Secreted.

Cell Line Specificity

Low cancer specificity

Function

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.

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