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Anti-CD55 Monoclonal Antibody (LU30)
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Product Description:The Anti-CD55 antibody is a human monoclonal antibody recommended for use in immunohistochemistry, enzyme-linked immunosorbent assay, western blot and other applications. This antibody specifically targets CD55 and demonstrates reactivity with human.Applications:Immunohistochemistry, Enzyme-Linked Immunosorbent Assay, Western BlotTarget:CD55Target Species:HumanSpecificity:This antibody reacts with Human CD55.Immunogen:Human CD55 antigen.Clonality:MonoclonalClone ID:LU30Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-CD55 Monoclonal Antibody (LU30) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
CD55
Protein Name
Complement decay-accelerating factor
Introduction
This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins.
Alternative Names
CR; CROM; DAF; TC
Gene ID
UniProt
Subcellular Location
Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor. Isoform 3: Secreted
Tissue Specificity
Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix.
Cell Line Specificity
Low cancer specificity
Function
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.
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