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Anti-CD46 Monoclonal Antibody (15C5)
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Product Description:The Anti-CD46 antibody is a human monoclonal antibody recommended for use in ELISA, functional assay and other applications. This antibody specifically targets CD46 and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Functional AssayTarget:CD46Target Species:HumanSpecificity:This antibody reacts with human CD46 (cluster of differentiation 46).Clonality:MonoclonalClone ID:15C5Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-CD46 Monoclonal Antibody (15C5) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
CD46
Protein Name
Membrane cofactor protein
Introduction
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome.
Alternative Names
MCP; TLX; AHUS2; MIC10; TRA2.10; CD46
Gene ID
UniProt
Molecule Mass
Adhesion Molecules, CD Molecules
Related Disease
Hemolytic uremic syndrome, atypical, 2 (AHUS2)
Subcellular Location
Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane
Tissue Specificity
Expressed by all cells except erythrocytes.
Cell Line Specificity
Low cancer specificity
Function
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
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