Anti-CD40 Monoclonal Antibody (5D12)

Subcat	Description	Isotype	Conjugate	Price
ASPC1472	Anti-CD40 Antibody (5D12)	Human IgG4, Kappa	None	$530	Add
ASPC1472-A	Anti-CD40 Antibody (5D12), APC	Human IgG4, Kappa	APC	$1,030	Add
ASPC1472-B	Anti-CD40 Antibody (5D12), Biotin	Human IgG4, Kappa	Biotin	$760	Add
ASPC1472-H	Anti-CD40 Antibody (5D12), HRP	Human IgG4, Kappa	HRP	$680	Add
ASPC1472-P	Anti-CD40 Antibody (5D12), PE	Human IgG4, Kappa	PE	$1,280	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC1472

Anti-CD40 Antibody (5D12)

Human IgG4, Kappa

None

$530

Add

ASPC1472-A

Anti-CD40 Antibody (5D12), APC

Human IgG4, Kappa

APC

$1,030

Add

ASPC1472-B

Anti-CD40 Antibody (5D12), Biotin

Human IgG4, Kappa

Biotin

$760

Add

ASPC1472-H

Anti-CD40 Antibody (5D12), HRP

Human IgG4, Kappa

HRP

$680

Add

ASPC1472-P

Anti-CD40 Antibody (5D12), PE

Human IgG4, Kappa

$1,280

Add

Anti-CD40 Monoclonal Antibody (5D12)
- Product Description:
  
  The Anti-CD40 antibody is a human monoclonal antibody recommended for immunohistochemistry, flow cytometry, enzyme-linked immunosorbent assay, blocking, surface plasmon resonance, immunoprecipitation and other applications. This antibody specifically targets CD40 and demonstrates reactivity with human and cynomolgus monkey.
  
  Applications:
  
  Immunohistochemistry, Flow Cytometry, Enzyme-Linked Immunosorbent Assay, Blocking, Surface Plasmon Resonance, Immunoprecipitation
  
  Source:
  
  Human
  
  Target:
  
  CD40
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human and cynomolgus monkey CD40.
  
  Immunogen:
  
  Human CD40
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  5D12
  
  Isotype:
  
  Human IgG4, Kappa
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  The concentration of the antibody is 1 mg/mL, but it may vary depending on the specific lot.
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  Azide free
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CD40 Monoclonal Antibody (5D12) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CD40

Protein Name

Tumor necrosis factor receptor superfamily member 5

Introduction

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3).

Alternative Names

CD40; p50; Bp50; CDW40; TNFRSF5

Gene ID

958

UniProt

P25942

Tissue Specificity

B-cells and in primary carcinomas.

Cell Line Specificity

Cancer enhanced (Lymphoma)

Function

Receptor for TNFSF5/CD40LG.