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Anti-CD4 Monoclonal Antibody (M-T310)
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Product Description:The M-T310 antibody specifically recognizes an epitope within the D1 domain of the CD4 molecule. The D1 domain is the outermost extracellular domain of CD4 and is crucial for its function.Applications:Immunohistochemistry - Paraffin, Immunoprecipitation, Western Blot, Flow Cytometry, ImmunofluorescenceSource:MouseTarget:CD4Specificity:This antibody recognizes the extracellular domain D1 of CD4.Clonality:MonoclonalClone ID:M-T310Isotype:Mouse IgG1, KappaPurification:The antibody was purified by Protein A.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for customized product form or formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-CD4 Monoclonal Antibody (M-T310) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
CD4
Protein Name
T-cell surface glycoprotein CD4
Molecular Family
CD Molecules
Introduction
This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system.
Alternative Names
CD4 Molecule; T-Cell Surface Glycoprotein CD4; T-Cell Surface Antigen T4/Leu-3; CD4 Antigen (P55); CD4 Receptor; CD4 Antigen; CD4mut
Gene ID
UniProt
Related Disease
Immunodeficiency 79 (IMD79)
Subcellular Location
Plasma membrane
Tissue Specificity
Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.
Cell Type
Epithelial cells, Langerhans cells, Dendritic cells
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