Anti-CD3E Monoclonal Antibody (898H2-6-15)

Subcat	Description	Isotype	Conjugate	Price
ASPC958	Anti-CD3E Antibody (898H2-6-15)	Mouse IgG2a, Kappa	None	$460	Add
ASPC958-A	Anti-CD3E Antibody (898H2-6-15), APC	Mouse IgG2a, Kappa	APC	$980	Add
ASPC958-B	Anti-CD3E Antibody (898H2-6-15), Biotin	Mouse IgG2a, Kappa	Biotin	$680	Add
ASPC958-H	Anti-CD3E Antibody (898H2-6-15), HRP	Mouse IgG2a, Kappa	HRP	$600	Add
ASPC958-P	Anti-CD3E Antibody (898H2-6-15), PE	Mouse IgG2a, Kappa	PE	$1,180	Add

Anti-CD3E Monoclonal Antibody (898H2-6-15)
- Product Description:
  
  The Anti-CD3E antibody is a mouse monoclonal antibody recommended for use in immunohistochemistry, flow cytometry and other applications. This antibody specifically targets CD3E and demonstrates reactivity with Porcine.
  
  Applications:
  
  Immunohistochemistry, Flow Cytometry
  
  Target:
  
  CD3E
  
  Specificity:
  
  This antibody reacts with CD3E.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  898H2-6-15
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CD3E Monoclonal Antibody (898H2-6-15) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CD3E

Protein Name

T-cell surface glycoprotein CD3 epsilon chain

Introduction

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency.

Alternative Names

CD3e Molecule; CD3e Antigen, Epsilon Polypeptide (TiT3 Complex); T-Cell Surface Antigen T3/Leu-4 Epsilon Chain; CD3e Molecule, Epsilon (CD3-TCR Complex); T3E; T-Cell Antigen Receptor Complex, Epsilon Subunit Of T3

Gene ID

397455

UniProt

Q7YRN2

Subcellular Location

Cell membrane

Function

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Also participates in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (By similarity). In addition to its role as a TCR coreceptor, it serves as a receptor for ITPRIPL1. Ligand recognition inhibits T-cell activation by promoting interaction with NCK1, which prevents CD3E-ZAP70 interaction and blocks the ERK-NFkB signaling cascade and calcium influx (By similarity).

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