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Anti-CD3E Monoclonal Antibody (12F6)
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Product Description:The Anti-CD3E antibody is a mouse monoclonal antibody recommended for flow cytometry, activation and other applications. This antibody specifically targets CD3E and demonstrates reactivity with human.Applications:Flow Cytometry, ActivationTarget:CD3ETarget Species:HumanSpecificity:This antibody reacts with human CD3E.Immunogen:Human CD3Clonality:MonoclonalClone ID:12F6Isotype:Mouse IgG2a, KappaPurification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:The concentration of the antibody is 1 mg/mL, but it may vary depending on the specific lot.Form:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:Azide freeStabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-CD3E Monoclonal Antibody (12F6) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
CD3E
Protein Name
T-cell surface glycoprotein CD3 epsilon chain
Introduction
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency.
Alternative Names
CD3e Molecule; CD3e Antigen, Epsilon Polypeptide (TiT3 Complex); T-Cell Surface Antigen T3/Leu-4 Epsilon Chain; CD3e Molecule, Epsilon (CD3-TCR Complex); T3E; T-Cell Antigen Receptor Complex, Epsilon Subunit Of T3
Gene ID
UniProt
Related Disease
Immunodeficiency 18 (IMD18)
Subcellular Location
Cell membrane
Cell Line Specificity
Cancer enriched (Leukemia)
Function
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.
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