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Anti-CD38 Monoclonal Antibody (HB7)
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Product Description:The HB7 antibody is specific for the human CD38 protein, which is an approximately 45 kDa type II transmembrane protein.Applications:Immunoprecipitation, Flow CytometrySource:MouseTarget:CD38Target Species:HumanSpecificity:Human CD38Epitope:AA 273-285Clonality:MonoclonalClone ID:HB7Isotype:Mouse IgG1, KappaPurification:The antibody was purified by Protein A.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for customized product form or formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-CD38 Monoclonal Antibody (HB7) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
CD38
Protein Name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Molecular Family
Adhesion Molecules, CD Molecules
Introduction
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia.
Alternative Names
CD38 Molecule; ADP-Ribosyl Cyclase 1; 2-Phospho-Cyclic-ADP-Ribose Transferase; Cyclic ADP-Ribose Hydrolase 1; 2-Phospho-ADP-Ribosyl Cyclase; NAD(+) Nucleosidase; CD38 Antigen (P45); ADPRC 1; 2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase; Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase
Gene ID
UniProt
Subcellular Location
Plasma membrane
Tissue Specificity
Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
Cell Type
B cells, Lymphocytes, NK cells, T cells
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