-
Anti-CD38 Monoclonal Antibody (1C6)
-
Product Description:The Anti-CD38 antibody is a human monoclonal antibody recommended for use in ELISA, flow cytometry, immunofluorescence, functional assay and other applications. This antibody specifically targets CD38 and demonstrates reactivity with human and cynomolgus monkey.Applications:Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunofluorescence, Functional Assay, Western BlotTarget:CD38Target Species:HumanSpecificity:This antibody reacts with human CD38 (cluster of differentiation 38).Immunogen:Human CD38 proteinClonality:MonoclonalClone ID:1C6Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
-
-
Anti-CD38 Monoclonal Antibody (1C6) Applications
-
Note:Optimal dilutions/concentrations should be determined by the end user.
-
Gene Symbol
CD38
Protein Name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Introduction
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia.
Alternative Names
CD38 Molecule; ADP-Ribosyl Cyclase 1; 2-Phospho-Cyclic-ADP-Ribose Transferase; Cyclic ADP-Ribose Hydrolase 1; 2-Phospho-ADP-Ribosyl Cyclase; NAD(+) Nucleosidase; CD38 Antigen (P45); ADPRC 1; 2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase; Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase
Gene ID
UniProt
Molecule Mass
Adhesion Molecules, CD Molecules
Subcellular Location
Cell surface
Tissue Specificity
Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
Cell Line Specificity
Group enriched
Function
Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion.
Customer Reviews
There are no reviews for Product Name.
Submit a review and receive an Amazon gift card.
Publications
There are no publications for Product Name.
If you couldn't find the specific publication, you can:
Submit a Citation Get a Publication Reward
