Anti-CD276 Monoclonal Antibody (1C9)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC508	Anti-CD276 Antibody (1C9)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC508-P	Anti-CD276 Antibody (1C9), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC508-A	Anti-CD276 Antibody (1C9), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC508-H	Anti-CD276 Antibody (1C9), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC508-B	Anti-CD276 Antibody (1C9), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Anti-CD276 Monoclonal Antibody (1C9)
- Product Description:
  
  The Anti-CD276 antibody is a human monoclonal antibody recommended for use in ELISA, flow cytometry, immunofluorescence and other applications. This antibody specifically targets CD276 and demonstrates reactivity with human, mouse.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunofluorescence, Western Blot
  
  Target:
  
  CD276
  
  Specificity:
  
  This antibody reacts with human CD276.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  1C9
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CD276 Monoclonal Antibody (1C9) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CD276

Protein Name

CD276 antigen

Introduction

The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative Names

CD276 Molecule; Costimulatory Molecule; CD276 Antigen; B7 Homolog 3; 4Ig-B7-H3; B7-H3; B7H3; B7RP-2

Gene ID

80381

UniProt

Q5ZPR3

Molecule Mass

CD Molecules

Subcellular Location

Membrane

Cell Line Specificity

Low cancer specificity

Function

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

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