Anti-CD274 Monoclonal Antibody - Amerigo Scientific

Subcat	Description	Isotype	Conjugate	Price
ASPC953	Anti-CD274 Antibody	Mouse IgG2b, Kappa	None	$460	Add
ASPC953-A	Anti-CD274 Antibody, APC	Mouse IgG2b, Kappa	APC	$980	Add
ASPC953-B	Anti-CD274 Antibody, Biotin	Mouse IgG2b, Kappa	Biotin	$680	Add
ASPC953-H	Anti-CD274 Antibody, HRP	Mouse IgG2b, Kappa	HRP	$600	Add
ASPC953-P	Anti-CD274 Antibody, PE	Mouse IgG2b, Kappa	PE	$1,180	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC953

Anti-CD274 Antibody

Mouse IgG2b, Kappa

None

$460

Add

ASPC953-A

Anti-CD274 Antibody, APC

Mouse IgG2b, Kappa

APC

$980

Add

ASPC953-B

Anti-CD274 Antibody, Biotin

Mouse IgG2b, Kappa

Biotin

$680

Add

ASPC953-H

Anti-CD274 Antibody, HRP

Mouse IgG2b, Kappa

HRP

$600

Add

ASPC953-P

Anti-CD274 Antibody, PE

Mouse IgG2b, Kappa

$1,180

Add

Anti-CD274 Monoclonal Antibody
- Product Description:
  
  The Anti-CD274 antibody is a mouse monoclonal antibody recommended for use in immunohistochemistry, flow cytometry, blocking and other applications. This antibody specifically targets CD274 and demonstrates reactivity with human.
  
  Applications:
  
  Immunohistochemistry, Flow Cytometry, Blocking
  
  Target:
  
  CD274
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with Human CD274.
  
  Clonality:
  
  Monoclonal
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CD274 Monoclonal Antibody Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CD274

Protein Name

Programmed cell death 1 ligand 1

Introduction

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma.

Alternative Names

CD274; CD274 molecule; B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1

Gene ID

29126

UniProt

Q9NZQ7

Subcellular Location

Cell membrane

Tissue Specificity

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

Cell Line Specificity

Low cancer specificity

Function

Plays a critical role in induction and maintenance of immune tolerance to self.

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