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Anti-CD274 Monoclonal Antibody (7C12)
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Product Description:The Anti-CD274 antibody is a human monoclonal antibody recommended for use in ELISA, blocking and other applications. This antibody specifically targets CD274 and demonstrates reactivity with human, mouse, cynomolgus monkey.Applications:Enzyme-Linked Immunosorbent Assay, BlockingTarget:CD274Specificity:This antibody reacts with human, Mouse, Cynomolgus monkey CD274.Clonality:MonoclonalClone ID:7C12Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-CD274 Monoclonal Antibody (7C12) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
CD274
Protein Name
Programmed cell death 1 ligand 1
Introduction
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma.
Alternative Names
CD274; CD274 molecule; B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1
Gene ID
UniProt
Molecule Mass
Adhesion Molecules, CD Molecules, Immune Checkpoint Receptors
Subcellular Location
Cell membrane
Tissue Specificity
Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
Cell Line Specificity
Low cancer specificity
Function
Plays a critical role in induction and maintenance of immune tolerance to self.
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