Anti-CD19 Monoclonal Antibody (12A12)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC608	Anti-CD19 Antibody (12A12)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC608-P	Anti-CD19 Antibody (12A12), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC608-A	Anti-CD19 Antibody (12A12), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC608-H	Anti-CD19 Antibody (12A12), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC608-B	Anti-CD19 Antibody (12A12), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Anti-CD19 Monoclonal Antibody (12A12)
- Product Description:
  
  The Anti-CD19 antibody is a human monoclonal antibody recommended for use in cytotoxicity assay, Biolayer Interferometry, flow cytometry, functional assay, ELISA, western blot, Radioimmunoassay and other applications. This antibody specifically targets CD19 and demonstrates reactivity with human.
  
  Applications:
  
  Cytotoxicity Assay, Biolayer Interferometry, Flow Cytometry, Functional Assay, Enzyme-Linked Immunosorbent Assay, Western Blot, Radioimmunoassay
  
  Target:
  
  CD19
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human CD19.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  12A12
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CD19 Monoclonal Antibody (12A12) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CD19

Protein Name

B-lymphocyte antigen CD19

Introduction

This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections.

Alternative Names

CD19 Molecule; B-Lymphocyte Surface Antigen B4; T-Cell Surface Antigen Leu-12; Differentiation Antigen CD19; CD19 Antigen; B-Lymphocyte Antigen CD19; CVID3; B4

Gene ID

930

UniProt

P15391

Molecule Mass

CD Molecules

Related Disease

Immunodeficiency, common variable, 3 (CVID3)

Subcellular Location

Cell membrane

Cell Line Specificity

Group enriched