Anti-CCR5 Monoclonal Antibody (2C6)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC233	Anti-CCR5 Antibody (2C6)	Mouse IgG1, Kappa	None	$460	In stock	Add
ASPC233-P	Anti-CCR5 Antibody (2C6), PE	Mouse IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC233-A	Anti-CCR5 Antibody (2C6), APC	Mouse IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC233-H	Anti-CCR5 Antibody (2C6), HRP	Mouse IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC233-B	Anti-CCR5 Antibody (2C6), Biotin	Mouse IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Anti-CCR5 Monoclonal Antibody (2C6)
- Product Description:
  
  The Anti-CCR5 antibody is a mouse monoclonal antibody recommended for use in blocking, ELISA, flow cytometry and other applications. This antibody specifically targets CCR5 and demonstrates reactivity with human.
  
  Applications:
  
  Blocking, Enzyme-Linked Immunosorbent Assay, Flow Cytometry
  
  Target:
  
  CCR5
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human CCR5.
  
  Immunogen:
  
  Recombinant Human CCR5 protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  2C6
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CCR5 Monoclonal Antibody (2C6) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CCR5

Protein Name

C-C chemokine receptor type 5

Introduction

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.

Alternative Names

CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; C-C chemokine receptor type 5; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A

Gene ID

1234

UniProt

P51681

Molecule Mass

CD Molecules, Cytokine/Chemokine Receptors, GPCR

Related Disease

Type 1 diabetes mellitus 22 (T1D22)

Subcellular Location

Cell membrane

Tissue Specificity

Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.

Cell Line Specificity

Cancer enhanced

Function

Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.

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