Anti-CCR4 Monoclonal Antibody (10F12)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC745	Anti-CCR4 Antibody (10F12)	Mouse IgG1, Kappa	None	$460	In stock	Add
ASPC745-P	Anti-CCR4 Antibody (10F12), PE	Mouse IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC745-A	Anti-CCR4 Antibody (10F12), APC	Mouse IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC745-H	Anti-CCR4 Antibody (10F12), HRP	Mouse IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC745-B	Anti-CCR4 Antibody (10F12), Biotin	Mouse IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC745

Anti-CCR4 Antibody (10F12)

Mouse IgG1, Kappa

None

$460

In stock

Add

ASPC745-P

Anti-CCR4 Antibody (10F12), PE

Mouse IgG1, Kappa

$1,180

2-3 weeks

Add

ASPC745-A

Anti-CCR4 Antibody (10F12), APC

Mouse IgG1, Kappa

APC

$980

2-3 weeks

Add

ASPC745-H

Anti-CCR4 Antibody (10F12), HRP

Mouse IgG1, Kappa

HRP

$600

2-3 weeks

Add

ASPC745-B

Anti-CCR4 Antibody (10F12), Biotin

Mouse IgG1, Kappa

Biotin

$680

2-3 weeks

Add

Anti-CCR4 Monoclonal Antibody (10F12)
- Product Description:
  
  The Anti-CCR4 antibody is a mouse monoclonal antibody recommended for use in flow cytometry, immunohistochemistry and other applications. This antibody specifically targets CCR4 and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry
  
  Target:
  
  CCR4
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human CCR4.
  
  Immunogen:
  
  Recombinant Human C-C Motif Chemokine Receptor 4 protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  10F12
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CCR4 Monoclonal Antibody (10F12) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CCR4

Protein Name

C-C chemokine receptor type 4

Introduction

The protein encoded by this gene belongs to the G-protein-coupled receptor family. It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

Alternative Names

CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099

Gene ID

1233

UniProt

P51679

Molecule Mass

CD Molecules, Cytokine/Chemokine Receptors, GPCR

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Cell Line Specificity

Cancer enriched

Function

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

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