Anti-CCN1 Monoclonal Antibody (12B11)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC625	Anti-CCN1 Antibody (12B11)	Mouse IgG1, Kappa	None	$460	In stock	Add
ASPC625-P	Anti-CCN1 Antibody (12B11), PE	Mouse IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC625-A	Anti-CCN1 Antibody (12B11), APC	Mouse IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC625-H	Anti-CCN1 Antibody (12B11), HRP	Mouse IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC625-B	Anti-CCN1 Antibody (12B11), Biotin	Mouse IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC625

Anti-CCN1 Antibody (12B11)

Mouse IgG1, Kappa

None

$460

In stock

Add

ASPC625-P

Anti-CCN1 Antibody (12B11), PE

Mouse IgG1, Kappa

$1,180

2-3 weeks

Add

ASPC625-A

Anti-CCN1 Antibody (12B11), APC

Mouse IgG1, Kappa

APC

$980

2-3 weeks

Add

ASPC625-H

Anti-CCN1 Antibody (12B11), HRP

Mouse IgG1, Kappa

HRP

$600

2-3 weeks

Add

ASPC625-B

Anti-CCN1 Antibody (12B11), Biotin

Mouse IgG1, Kappa

Biotin

$680

2-3 weeks

Add

Anti-CCN1 Monoclonal Antibody (12B11)
- Product Description:
  
  The Anti-CCN1 antibody is a mouse monoclonal antibody recommended for use in inhibition, flow cytometry, ELISA, neutralization and other applications. This antibody specifically targets CCN1 and demonstrates reactivity with human.
  
  Applications:
  
  Inhibition, Flow Cytometry, Enzyme-Linked Immunosorbent Assay, Neutralization
  
  Target:
  
  CCN1
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human CCN1.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  12B11
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CCN1 Monoclonal Antibody (12B11) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CCN1

Protein Name

CCN family member 1

Introduction

The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation.

Alternative Names

GIG1; CYR61; IGFBP10

Gene ID

3491

UniProt

O00622

Subcellular Location

Secreted.

Cell Line Specificity

Low cancer specificity

Function

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

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