Anti-C9orf72 Monoclonal Antibody (15B6)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC717	Anti-C9orf72 Antibody (15B6)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC717-P	Anti-C9orf72 Antibody (15B6), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC717-A	Anti-C9orf72 Antibody (15B6), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC717-H	Anti-C9orf72 Antibody (15B6), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC717-B	Anti-C9orf72 Antibody (15B6), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC717

Anti-C9orf72 Antibody (15B6)

Human IgG1, Kappa

None

$460

In stock

Add

ASPC717-P

Anti-C9orf72 Antibody (15B6), PE

Human IgG1, Kappa

$1,180

2-3 weeks

Add

ASPC717-A

Anti-C9orf72 Antibody (15B6), APC

Human IgG1, Kappa

APC

$980

2-3 weeks

Add

ASPC717-H

Anti-C9orf72 Antibody (15B6), HRP

Human IgG1, Kappa

HRP

$600

2-3 weeks

Add

ASPC717-B

Anti-C9orf72 Antibody (15B6), Biotin

Human IgG1, Kappa

Biotin

$680

2-3 weeks

Add

Anti-C9orf72 Monoclonal Antibody (15B6)
- Product Description:
  
  The Anti-C9orf72 antibody is a human monoclonal antibody recommended for use in neutralization, flow cytometry, blocking, functional assay, western blot and other applications. This antibody specifically targets C9orf72 and demonstrates reactivity with human.
  
  Applications:
  
  Neutralization, Flow Cytometry, Blocking, Functional Assay, Western Blot
  
  Target:
  
  C9orf72
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human C9orf72.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  15B6
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-C9orf72 Monoclonal Antibody (15B6) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

C9orf72

Protein Name

Guanine nucleotide exchange factor C9orf72

Introduction

The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia).

Alternative Names

Dipeptide repeats; Dprs; ALSFTD; FTDALS; DENNL72; FTDALS1

Gene ID

203228

UniProt

Q96LT7

Related Disease

Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 (FTDALS1)

Subcellular Location

Nucleus

Tissue Specificity

Both isoforms are widely expressed, including kidney, lung, liver, heart, testis and several brain regions, such as cerebellum. Also expressed in the frontal cortex and in lymphoblasts (at protein level).

Cell Line Specificity

Low cancer specificity

Function

Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy.

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