Anti-C5 Monoclonal Antibody (Eculizumab)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC015	Anti-C5 Antibody (Eculizumab)	Human IgG2/4, Kappa	None	$460	In stock	Add
ASPC015-P	Anti-C5 Antibody (Eculizumab), PE	Human IgG2/4, Kappa	PE	$1,180	2-3 weeks	Add
ASPC015-A	Anti-C5 Antibody (Eculizumab), APC	Human IgG2/4, Kappa	APC	$980	2-3 weeks	Add
ASPC015-H	Anti-C5 Antibody (Eculizumab), HRP	Human IgG2/4, Kappa	HRP	$600	2-3 weeks	Add
ASPC015-B	Anti-C5 Antibody (Eculizumab), Biotin	Human IgG2/4, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC015

Anti-C5 Antibody (Eculizumab)

Human IgG2/4, Kappa

None

$460

In stock

Add

ASPC015-P

Anti-C5 Antibody (Eculizumab), PE

Human IgG2/4, Kappa

$1,180

2-3 weeks

Add

ASPC015-A

Anti-C5 Antibody (Eculizumab), APC

Human IgG2/4, Kappa

APC

$980

2-3 weeks

Add

ASPC015-H

Anti-C5 Antibody (Eculizumab), HRP

Human IgG2/4, Kappa

HRP

$600

2-3 weeks

Add

ASPC015-B

Anti-C5 Antibody (Eculizumab), Biotin

Human IgG2/4, Kappa

Biotin

$680

2-3 weeks

Add

Anti-C5 Monoclonal Antibody (Eculizumab)
- Product Description:
  
  Eculizumab binds to the complement protein C5, preventing its cleavage into C5a and C5b.
  
  Applications:
  
  Inhibition, Enzyme-Linked Immunosorbent Assay, Immunoprecipitation, Functional Assay
  
  Target:
  
  C5
  
  Target Species:
  
  Human
  
  Specificity:
  
  Human C5
  
  Immunogen:
  
  Human C5
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  Eculizumab
  
  Isotype:
  
  Human IgG2/4, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-C5 Monoclonal Antibody (Eculizumab) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

Protein Name

Complement C5

Introduction

This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC).

Alternative Names

C5, CPAMD4, Complement C5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4

Gene ID

727

UniProt

P01031

Related Disease

Complement component 5 deficiency (C5D)

Cell Type

Endothelial cells, Epithelial cells

Function

Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.

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