Anti-C2 Monoclonal Antibody (14G10)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC301	Anti-C2 Antibody (14G10)	Mouse IgG2b, Kappa	None	$460	In stock	Add
ASPC301-P	Anti-C2 Antibody (14G10), PE	Mouse IgG2b, Kappa	PE	$1,180	2-3 weeks	Add
ASPC301-A	Anti-C2 Antibody (14G10), APC	Mouse IgG2b, Kappa	APC	$980	2-3 weeks	Add
ASPC301-H	Anti-C2 Antibody (14G10), HRP	Mouse IgG2b, Kappa	HRP	$600	2-3 weeks	Add
ASPC301-B	Anti-C2 Antibody (14G10), Biotin	Mouse IgG2b, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC301

Anti-C2 Antibody (14G10)

Mouse IgG2b, Kappa

None

$460

In stock

Add

ASPC301-P

Anti-C2 Antibody (14G10), PE

Mouse IgG2b, Kappa

$1,180

2-3 weeks

Add

ASPC301-A

Anti-C2 Antibody (14G10), APC

Mouse IgG2b, Kappa

APC

$980

2-3 weeks

Add

ASPC301-H

Anti-C2 Antibody (14G10), HRP

Mouse IgG2b, Kappa

HRP

$600

2-3 weeks

Add

ASPC301-B

Anti-C2 Antibody (14G10), Biotin

Mouse IgG2b, Kappa

Biotin

$680

2-3 weeks

Add

Anti-C2 Monoclonal Antibody (14G10)
- Product Description:
  
  The Anti-C2 antibody is a mouse monoclonal antibody recommended for use in inhibition, western blot and other applications. This antibody specifically targets C2 and demonstrates reactivity with human.
  
  Applications:
  
  Inhibition, Western Blot
  
  Target:
  
  C2
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human C2.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  14G10
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-C2 Monoclonal Antibody (14G10) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

Protein Name

Complement C2

Introduction

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.

Alternative Names

C2; complement component 2; CO2; ARMD14; complement C2; C3/C5 convertase; complement component C2

Gene ID

717

UniProt

P06681

Related Disease

Macular degeneration, age-related, 14 (ARMD14)

Subcellular Location

Secreted.

Cell Line Specificity

Group enriched

Function

Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.

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