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Anti-BMPR1A Monoclonal Antibody (AbD1556)
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Product Description:The Anti-BMPR1A antibody is a human monoclonal antibody recommended for use in enzyme-linked immunosorbent assay, surface plasmon resonance, blocking and other applications. This antibody specifically targets BMPR1A and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Surface Plasmon Resonance, BlockingTarget:BMPR1ATarget Species:HumanSpecificity:This antibody reacts with Human BMPR1A.Immunogen:BMPR1A proteinClonality:MonoclonalClone ID:AbD1556Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-BMPR1A Monoclonal Antibody (AbD1556) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
BMPR1A
Protein Name
Bone morphogenetic protein receptor type-1A
Introduction
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
Alternative Names
10q23del; ACVRLK3; ALK3; CD292; SKR5
Gene ID
UniProt
Subcellular Location
Cell membrane
Tissue Specificity
Highly expressed in skeletal muscle.
Cell Line Specificity
Low cancer specificity
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity).
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