Anti-AXL Monoclonal Antibody (4C6)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC635	Anti-AXL Antibody (4C6)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC635-P	Anti-AXL Antibody (4C6), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC635-A	Anti-AXL Antibody (4C6), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC635-H	Anti-AXL Antibody (4C6), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC635-B	Anti-AXL Antibody (4C6), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Anti-AXL Monoclonal Antibody (4C6)
- Product Description:
  
  The Anti-AXL antibody is a human monoclonal antibody recommended for use in ELISA and other applications. This antibody specifically targets AXL and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay
  
  Target:
  
  AXL
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human AXL.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  4C6
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-AXL Monoclonal Antibody (4C6) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

AXL

Protein Name

Tyrosine-protein kinase receptor UFO

Introduction

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus.

Alternative Names

ARK; UFO; JTK11; Tyro7

Gene ID

558

UniProt

P30530

Molecule Mass

Cytokine/Chemokine Receptors, Cytokines/Chemokines

Subcellular Location

Cell membrane

Tissue Specificity

Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.

Cell Line Specificity

Cancer enhanced

Function

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.

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