Anti-ATP5F1B Monoclonal Antibody (10B4)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC738	Anti-ATP5F1B Antibody (10B4)	Mouse IgG2a, Kappa	None	$460	In stock	Add
ASPC738-P	Anti-ATP5F1B Antibody (10B4), PE	Mouse IgG2a, Kappa	PE	$1,180	2-3 weeks	Add
ASPC738-A	Anti-ATP5F1B Antibody (10B4), APC	Mouse IgG2a, Kappa	APC	$980	2-3 weeks	Add
ASPC738-H	Anti-ATP5F1B Antibody (10B4), HRP	Mouse IgG2a, Kappa	HRP	$600	2-3 weeks	Add
ASPC738-B	Anti-ATP5F1B Antibody (10B4), Biotin	Mouse IgG2a, Kappa	Biotin	$680	2-3 weeks	Add

Anti-ATP5F1B Monoclonal Antibody (10B4)
- Product Description:
  
  The Anti-ATP5F1B antibody is a mouse monoclonal antibody recommended for use in ELISA, western blot, immunofluorescence, immunohistochemistry and other applications. This antibody specifically targets ATP5F1B and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Western Blot, Immunofluorescence, Immunohistochemistry
  
  Target:
  
  ATP5F1B
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human ATP5F1B.
  
  Immunogen:
  
  Human ATP Synthase F1 Subunit Beta
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  10B4
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-ATP5F1B Monoclonal Antibody (10B4) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

ATP5F1B

Protein Name

ATP synthase subunit beta, mitochondrial

Introduction

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core.

Alternative Names

ATP Synthase F1 Subunit Beta; ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Beta Polypeptide; ATP5B; EC 3.6.3.14; ATPSB; ATPMB; Mitochondrial ATP Synthetase, Beta Subunit

Gene ID

506

UniProt

P06576

Related Disease

Hypermetabolism due to uncoupled mitochondrial oxidative phosphorylation 2 (HUMOP2)

Subcellular Location

Mitochondrion inner membrane

Cell Line Specificity

Low cancer specificity

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

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