Anti-ASPH Monoclonal Antibody (13C5)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC179	Anti-ASPH Antibody (13C5)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC179-P	Anti-ASPH Antibody (13C5), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC179-A	Anti-ASPH Antibody (13C5), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC179-H	Anti-ASPH Antibody (13C5), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC179-B	Anti-ASPH Antibody (13C5), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Anti-ASPH Monoclonal Antibody (13C5)
- Product Description:
  
  The Anti-ASPH antibody is a human monoclonal antibody recommended for use in immunofluorescence, flow cytometry, functional assay and other applications. This antibody specifically targets ASPH and demonstrates reactivity with human.
  
  Applications:
  
  Immunofluorescence, Flow Cytometry, Functional Assay
  
  Target:
  
  ASPH
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human aspartate beta-hydroxylase.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  13C5
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-ASPH Monoclonal Antibody (13C5) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

ASPH

Protein Name

Aspartyl/asparaginyl beta-hydroxylase

Introduction

This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.

Alternative Names

ASPH; aspartate beta-hydroxylase; AAH; BAH; HAAH; JCTN; FDLAB; junctin; CASQ2BP1; aspartyl/asparaginyl beta-hydroxylase; humbug; junctate; A beta H-J-J; cardiac junctin; ASP beta-hydroxylase; peptide-aspartate beta-dioxygenase; aspartyl/asparaginyl-beta-h

Gene ID

444

UniProt

Q12797

Related Disease

Facial dysmorphism, lens dislocation, anterior segment abnormalities, and spontaneous filtering blebs (FDLAB)

Tissue Specificity

Isoform 1 is detected in all tissues tested. Isoform 8 is mainly expressed in pancreas, heart, brain, kidney and liver. Isoform 8 is expressed in kidney (at protein level).

Cell Line Specificity

Low cancer specificity

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