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Anti-ASCL1 Monoclonal Antibody (SC72.2)
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Product Description:The Anti-ASCL1 antibody is a mouse monoclonal antibody recommended for use in immunohistochemistry, enzyme-linked immunosorbent assay and other applications. This antibody specifically targets ASCL1 and demonstrates reactivity with human.Applications:Immunohistochemistry, Enzyme-Linked Immunosorbent AssaySource:MouseTarget:ASCL1Target Species:HumanSpecificity:This antibody reacts with Human ASCL1.Immunogen:ASCL1 protein.Clonality:MonoclonalClone ID:SC72.2Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-ASCL1 Monoclonal Antibody (SC72.2) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
ASCL1
Protein Name
Achaete-scute homolog 1
Introduction
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.
Alternative Names
ASH1; HASH1; MASH1; bHLHa46
Gene ID
UniProt
Subcellular Location
Nucleus
Cell Line Specificity
Group enriched
Function
Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach (By similarity).
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