Anti-APP Monoclonal Antibody (6E10)

Subcat	Description	Isotype	Conjugate	Price
ASPC1442	Anti-APP Antibody (6E10)	Mouse IgG1, Kappa	None	$530	Add
ASPC1442-A	Anti-APP Antibody (6E10), APC	Mouse IgG1, Kappa	APC	$1,030	Add
ASPC1442-B	Anti-APP Antibody (6E10), Biotin	Mouse IgG1, Kappa	Biotin	$760	Add
ASPC1442-H	Anti-APP Antibody (6E10), HRP	Mouse IgG1, Kappa	HRP	$680	Add
ASPC1442-P	Anti-APP Antibody (6E10), PE	Mouse IgG1, Kappa	PE	$1,280	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC1442

Anti-APP Antibody (6E10)

Mouse IgG1, Kappa

None

$530

Add

ASPC1442-A

Anti-APP Antibody (6E10), APC

Mouse IgG1, Kappa

APC

$1,030

Add

ASPC1442-B

Anti-APP Antibody (6E10), Biotin

Mouse IgG1, Kappa

Biotin

$760

Add

ASPC1442-H

Anti-APP Antibody (6E10), HRP

Mouse IgG1, Kappa

HRP

$680

Add

ASPC1442-P

Anti-APP Antibody (6E10), PE

Mouse IgG1, Kappa

$1,280

Add

Anti-APP Monoclonal Antibody (6E10)
- Product Description:
  
  The Anti-APP antibody is a mouse monoclonal antibody recommended for immunohistochemistry, electron microscopy, enzyme-linked immunosorbent assay, western blot, immunoprecipitation and other applications. This antibody specifically targets APP and demonstrates reactivity with human.
  
  Applications:
  
  Immunohistochemistry, Electron Microscopy, Enzyme-Linked Immunosorbent Assay, Western Blot, Immunoprecipitation
  
  Target:
  
  APP
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human APP.
  
  Immunogen:
  
  Human Amyloid-beta peptide.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  6E10
  
  Isotype:
  
  Mouse IgG1, Kappa
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  The concentration of the antibody is 1 mg/mL, but it may vary depending on the specific lot.
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  Azide free
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-APP Monoclonal Antibody (6E10) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

APP

Protein Name

Amyloid-beta precursor protein

Introduction

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Alternative Names

AAA; ABETA; ABPP; AD1I; CTFgamma; CVAP; PN-II; PN2; APP

Gene ID

351

UniProt

P05067

Related Disease

Alzheimer disease, Amyloidosis, Neurodegeneration

Subcellular Location

Cell membrane

Cell Line Specificity

Low cancer specificity

Function

Heparin-binding, Protease inhibitor, Serine protease inhibitor

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