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Anti-ANTXR1 Monoclonal Antibody (2A7)
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Product Description:The Anti-ANTXR1 antibody is a human monoclonal antibody recommended for use in flow cytometry, immunofluorescence, functional assay, inhibition, immunohistochemistry, ELISA, cytotoxicity assay and other applications. This antibody specifically targets ANTXR1 and demonstrates reactivity with human.Applications:Flow Cytometry, Immunofluorescence, Functional Assay, Inhibition, Immunohistochemistry, Enzyme-Linked Immunosorbent Assay, Cytotoxicity AssayTarget:ANTXR1Target Species:HumanSpecificity:This antibody reacts with human TEM8.Clonality:MonoclonalClone ID:2A7Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-ANTXR1 Monoclonal Antibody (2A7) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
ANTXR1
Protein Name
Anthrax toxin receptor 1
Introduction
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
Alternative Names
ANTXR1; anthrax toxin receptor 1; ATR; GAPO; TEM8; 2310008J16Rik; 2810405N18Rik; tumor endothelial marker 8
Gene ID
UniProt
Related Disease
Hemangioma, capillary infantile (HCI)
Subcellular Location
Cell membrane
Tissue Specificity
Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
Cell Line Specificity
Cancer enhanced
Function
Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
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