Anti-ALDH7A1 Monoclonal Antibody (D-10A11)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Size	Price	Quantity
ASZ1C102	Anti-ALDH7A1 Antibody (D-10A11)	Mouse IgG1, Kappa		None		$460		Add

Anti-ALDH7A1 Monoclonal Antibody (D-10A11)
- Product Description:
  
  The Anti-ALDH7A1 antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human, mouse and rat ALDH7A1.
  
  Applications:
  
  Immunohistochemistry, Immunocytochemistry, Western Blot, Immunoprecipitation
  
  Source:
  
  Mouse
  
  Target:
  
  ALDH7A1
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human Aldehyde Dehydrogenase 7 Family Member A1 (ALDH7A1).
  
  Immunogen:
  
  Recombinant ALDH7A1 protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  D-10A11
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  0.02% sodium azide
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-ALDH7A1 Monoclonal Antibody (D-10A11) Applications
- Recommended Dilution:
  
  Western Blot: 0.01-2 µg/mL
  Immunohistochemistry: 5-20 µg/mL
  Immunocytochemistry: 5-20 µg/mL
  
  Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Protein Name

Alpha-aminoadipic semialdehyde dehydrogenase

Introduction

The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified.

Alternative Names

ATQ1; EPD; PDE

Gene ID

501

UniProt

P49419

Related Disease

Epilepsy, early-onset, 4, vitamin B6-dependent (EPEO4)

Tissue Specificity

Abundant in hepatoma cells and fetal cochlea, ovary, eye, heart, adrenal gland, liver and kidney. Low levels present in adult peripheral blood leukocytes and fetal brain, thymus, spleen, skeletal muscle, lung and tongue.

Cell Line Specificity

Cancer enhanced

Function

Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.

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