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Anti-AHRR Monoclonal Antibody (G-5B1)
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Product Description:The Anti-AHRR antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human AHRR.Applications:Immunohistochemistry, Immunocytochemistry, Western Blot, ImmunoprecipitationSource:MouseTarget:AHRRTarget Species:HumanSpecificity:This antibody reacts with human Aryl-Hydrocarbon Receptor Repressor (AHRR).Clonality:MonoclonalClone ID:G-5B1Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEConcentration:1 mg/mLForm:LiquidFormulation:Contact us for custom product formulation.Preservative:0.02% sodium azideShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-AHRR Monoclonal Antibody (G-5B1) Applications
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Recommended Dilution:Western Blot: 1:500-1:5000
Immunohistochemistry: 1:50-1:200
Immunocytochemistry: 1:50-1:200Note:Optimal dilutions/concentrations should be determined by the end user.
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Protein Name
Aryl hydrocarbon receptor repressor
Introduction
The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Alternative Names
AHH; AHHR; bHLHe77
Gene ID
UniProt
Subcellular Location
Cytoplasm
Tissue Specificity
Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary.
Function
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
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