-
Anti-ACVRL1 Monoclonal Antibody (6C12)
-
Product Description:The Anti-ACVRL1 antibody is a human monoclonal antibody recommended for use in ELISA, immunohistochemistry and other applications. This antibody specifically targets ACVRL1 and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, ImmunohistochemistryTarget:ACVRL1Target Species:HumanSpecificity:This antibody reacts with human ACVRL1.Clonality:MonoclonalClone ID:6C12Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
-
-
Anti-ACVRL1 Monoclonal Antibody (6C12) Applications
-
Note:Optimal dilutions/concentrations should be determined by the end user.
-
Gene Symbol
ACVRL1
Protein Name
Activin receptor type-1-like
Introduction
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
Alternative Names
Activin A Receptor Type II-Like 1; TGF-B Superfamily Receptor Type I; EC 2.7.11.30; ACVRLK1; TSR-I; ALK-1; ALK1; SKR3; Activin A Receptor, Type II-Like Kinase 1; Activin Receptor-Like Kinase 1; EC 2.7.11; HHT2; ORW2; HHT
Gene ID
UniProt
Related Disease
Telangiectasia, hereditary hemorrhagic, 2 (HHT2)
Subcellular Location
Cell membrane
Cell Line Specificity
Cancer enhanced
Function
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
Customer Reviews
There are no reviews for Product Name.
Submit a review and receive an Amazon gift card.
Publications
There are no publications for Product Name.
If you couldn't find the specific publication, you can:
Submit a Citation Get a Publication Reward
