Anti-ACVR2A Monoclonal Antibody (1F11)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC280	Anti-ACVR2A Antibody (1F11)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC280-P	Anti-ACVR2A Antibody (1F11), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC280-A	Anti-ACVR2A Antibody (1F11), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC280-H	Anti-ACVR2A Antibody (1F11), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC280-B	Anti-ACVR2A Antibody (1F11), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC280

Anti-ACVR2A Antibody (1F11)

Human IgG1, Kappa

None

$460

In stock

Add

ASPC280-P

Anti-ACVR2A Antibody (1F11), PE

Human IgG1, Kappa

$1,180

2-3 weeks

Add

ASPC280-A

Anti-ACVR2A Antibody (1F11), APC

Human IgG1, Kappa

APC

$980

2-3 weeks

Add

ASPC280-H

Anti-ACVR2A Antibody (1F11), HRP

Human IgG1, Kappa

HRP

$600

2-3 weeks

Add

ASPC280-B

Anti-ACVR2A Antibody (1F11), Biotin

Human IgG1, Kappa

Biotin

$680

2-3 weeks

Add

Anti-ACVR2A Monoclonal Antibody (1F11)
- Product Description:
  
  The Anti-ACVR2A antibody is a human monoclonal antibody recommended for use in ELISA, functional assay and other applications. This antibody specifically targets ACVR2A and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Functional Assay
  
  Target:
  
  ACVR2A
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human ActRIIA and ActRIIB.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  1F11
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-ACVR2A Monoclonal Antibody (1F11) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

ACVR2A

Protein Name

Activin receptor type-2A

Introduction

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.

Alternative Names

ACVR2A; activin A receptor, type IIA

Gene ID

UniProt

P27037

Subcellular Location

Cell membrane

Cell Line Specificity

Low cancer specificity

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).

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