Anti-AAV VP1 Monoclonal Antibody (A20)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC113	Anti-AAV VP1 Antibody (A20)	Mouse IgG1, Kappa	None	$460	In stock	Add
ASPC113-P	Anti-AAV VP1 Antibody (A20), PE	Mouse IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC113-A	Anti-AAV VP1 Antibody (A20), APC	Mouse IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC113-H	Anti-AAV VP1 Antibody (A20), HRP	Mouse IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC113-B	Anti-AAV VP1 Antibody (A20), Biotin	Mouse IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC113

Anti-AAV VP1 Antibody (A20)

Mouse IgG1, Kappa

None

$460

In stock

Add

ASPC113-P

Anti-AAV VP1 Antibody (A20), PE

Mouse IgG1, Kappa

$1,180

2-3 weeks

Add

ASPC113-A

Anti-AAV VP1 Antibody (A20), APC

Mouse IgG1, Kappa

APC

$980

2-3 weeks

Add

ASPC113-H

Anti-AAV VP1 Antibody (A20), HRP

Mouse IgG1, Kappa

HRP

$600

2-3 weeks

Add

ASPC113-B

Anti-AAV VP1 Antibody (A20), Biotin

Mouse IgG1, Kappa

Biotin

$680

2-3 weeks

Add

Anti-AAV VP1 Monoclonal Antibody (A20)
- Product Description:
  
  A20 is a monoclonal antibody that specifically recognizes a conformational epitope on the capsid protein VP1 of Adeno-associated virus. This antibody neutralizes AAV-2 and AAV-3B and it does not bind to the serotypes 1, 4, 5, 6, 8 and 9.
  
  Applications:
  
  Immunoprecipitation, Neutralization, Enzyme-Linked Immunosorbent Assay, Immunofluorescence
  
  Source:
  
  Mouse
  
  Target:
  
  AAV VP1
  
  Specificity:
  
  Adeno-associated virus type 2 (AAV-2)
  
  Immunogen:
  
  A combination of engineered AAV capsid proteins (VP1, VP2, and VP3).
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  A20
  
  Isotype:
  
  Mouse IgG1, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-AAV VP1 Monoclonal Antibody (A20) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

AAV2gp05

Protein Name

Capsid protein VP1

Introduction

Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.

Alternative Names

AAV-2 capsid proteins; Capsid protein VP1; AAV2; Adeno-associated virus 2 (isolate Srivastava/1982)

Gene ID

4192017

UniProt

P03135

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