Anti-PTPRC Monoclonal Antibody (BC8)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC137	Anti-PTPRC Antibody (BC8)	Mouse IgG1, Kappa	None	$460	In stock	Add
ASPC137-P	Anti-PTPRC Antibody (BC8), PE	Mouse IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC137-A	Anti-PTPRC Antibody (BC8), APC	Mouse IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC137-H	Anti-PTPRC Antibody (BC8), HRP	Mouse IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC137-B	Anti-PTPRC Antibody (BC8), Biotin	Mouse IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC137

Anti-PTPRC Antibody (BC8)

Mouse IgG1, Kappa

None

$460

In stock

Add

ASPC137-P

Anti-PTPRC Antibody (BC8), PE

Mouse IgG1, Kappa

$1,180

2-3 weeks

Add

ASPC137-A

Anti-PTPRC Antibody (BC8), APC

Mouse IgG1, Kappa

APC

$980

2-3 weeks

Add

ASPC137-H

Anti-PTPRC Antibody (BC8), HRP

Mouse IgG1, Kappa

HRP

$600

2-3 weeks

Add

ASPC137-B

Anti-PTPRC Antibody (BC8), Biotin

Mouse IgG1, Kappa

Biotin

$680

2-3 weeks

Add

Anti-PTPRC Monoclonal Antibody (BC8)
- Product Description:
  
  BC8 is a monoclonal antibody that specifically binds to CD45, a critical glycoprotein expressed on the surface of most hematopoietic cells.
  
  Applications:
  
  Functional Assay, Flow Cytometry
  
  Source:
  
  Mouse
  
  Target:
  
  PTPRC
  
  Target Species:
  
  Human
  
  Specificity:
  
  Human CD45
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  BC8
  
  Isotype:
  
  Mouse IgG1, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-PTPRC Monoclonal Antibody (BC8) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

PTPRC

Protein Name

Receptor-type tyrosine-protein phosphatase C

Introduction

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling.

Alternative Names

PTPRC; Receptor-type tyrosine-protein phosphatase C; CD45

UniProt

P08575

Related Disease

Multiple sclerosis (MS)

Subcellular Location

Nucleoplasm,Vesicles

Tissue Specificity

Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes.

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