Name: IRF 3 Recombinant Protein
Price: Inquiry

- Overview
  - IRF-3 Human Recombinant produced in E. Coli is a single, non-glycosylated, polypeptide chain containing 111 amino acids (1-112) and having a molecular mass of 13 kDa. The Interferon Regulatory Factor-3 is purified by proprietary chromatographic techniques. Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF-3 mediates interferon-stimulated response element (isre) promoter activation. Functions as a molecular switch for antiviral activity. Dsrna generated during the course of an viral infection leads to IRF3 phosphorylation on the c-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with creb binding protein (crebbp) to form dsrna-activated factor 1 (draf1), a complex which activates the transcription of genes under the control of isre. The complex binds to the ie and prdiii regions on the ifn-alpha and ifn-beta promoters respectively. IRF-3 does not have any transcription activation domains.
    
    Please contact us at for specific academic pricing.
- Properties
  - Protein Name
    
    IRF-3, IRF3, Interferon Regulatory Factor 3.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
    
    Formulation
    
    1mg/ml in phosphate-buffered saline (PBS), pH 7.4.
    
    Storage
    
    Liquid Interferon although stable at 10°C for 1 week, should be stored below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

IRF 3 Recombinant Protein

IRF 3 Recombinant Protein

We Also Recommend

IGF1 Recombinant Protein

IRF 5 Recombinant Protein

PODXL Mouse