Collagen Cell Carrier (CCC)

The Collagen Cell Carrier® membrane (CCC) is a mobile cell carrier developed for applications in tissue engineering and regenerative medicine. Exceptional native collagen fibers, isolated in their complex form from bovine skin represent a natural environment for adherent cells. The special feature: with their preserved strength the fibers build an ultrapure collagen membrane that is self-supportive and enables transfer and further processing of intact cell and tissue cultures on the natural matrix.

Standardized 2D or 3D cell-based assays
The CCC is a universal scaffold for adherent primary cells, cell lines and stem cells for in vitro and in vivo use. It creates a natural environment for cell attachment, growth and differentiation in applications ranging from simple cell monolayer cultures to the reconstruction of complex 3D tissue cultures on top of the membrane. As a universal matrix, the CCC facilitates the development of cell-based assays with authentic cell performance.
The strong membrane uniquely offers the opportunity to easily transfer the intact cell-matrix-complex and proceed to standard analyses, such as fluorescence microscopy, protein analysis or histology.
The standardized industrial production process optimized in more than 85 years ensures constant high quality of the biomaterial.

Implantation vehicle for easy bench-to-bedside translation
The versatile CCC is especially suited as a biological vehicle for cell implantation. It supports the formation of a robust cell-matrix association that can be sutured directly at the implantation site, fixing therapeutic cells to the target tissue.
The natural scaffold supports cells during and after implantation, thereby improving their survival. Depending on the target tissue, the CCC maintains its integrity for several weeks before complete biodegradation. Permeable for most soluble factors, it allows tissue nutrition and paracrine cell-to-cell communication. The elastic membrane facilitates tight adherence even to moving organs (e.g. heart muscle), bringing implanted cells in close proximity to the damaged tissue.
Our standardized collagen matrix is the ideal tool for research and development of ATMPs in tissue engineering and regenerative medicine, including cell therapy, implantology and medical devices.

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