Collagen Cell Carrier (CCC)

Catalog Number:
500042928-500057257
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      • Overview
        • The Collagen Cell Carrier® membrane (CCC) is a mobile cell carrier developed for applications in tissue engineering and regenerative medicine. Exceptional native collagen fibers, isolated in their complex form from bovine skin represent a natural environment for adherent cells. The special feature: with their preserved strength the fibers build an ultrapure collagen membrane that is self-supportive and enables transfer and further processing of intact cell and tissue cultures on the natural matrix.

          Standardized 2D or 3D cell-based assays
          The CCC is a universal scaffold for adherent primary cells, cell lines and stem cells for in vitro and in vivo use. It creates a natural environment for cell attachment, growth and differentiation in applications ranging from simple cell monolayer cultures to the reconstruction of complex 3D tissue cultures on top of the membrane. As a universal matrix, the CCC facilitates the development of cell-based assays with authentic cell performance.
          The strong membrane uniquely offers the opportunity to easily transfer the intact cell-matrix-complex and proceed to standard analyses, such as fluorescence microscopy, protein analysis or histology.
          The standardized industrial production process optimized in more than 85 years ensures constant high quality of the biomaterial.

          Implantation vehicle for easy bench-to-bedside translation
          The versatile CCC is especially suited as a biological vehicle for cell implantation. It supports the formation of a robust cell-matrix association that can be sutured directly at the implantation site, fixing therapeutic cells to the target tissue.
          The natural scaffold supports cells during and after implantation, thereby improving their survival. Depending on the target tissue, the CCC maintains its integrity for several weeks before complete biodegradation. Permeable for most soluble factors, it allows tissue nutrition and paracrine cell-to-cell communication. The elastic membrane facilitates tight adherence even to moving organs (e.g. heart muscle), bringing implanted cells in close proximity to the damaged tissue.
          Our standardized collagen matrix is the ideal tool for research and development of ATMPs in tissue engineering and regenerative medicine, including cell therapy, implantology and medical devices.

          Please contact us at  for specific academic pricing.

      • Properties
        • Concentration
          5 mg/ml
          Other Properties
          Pure collagen type I fibers from bovine skin
          Raw material for medical quality from countries with negligible BSE risk
          produced under ISO 9001 & ISO 13485 quality management system
          Available in research and medical grade
          Gamma-sterilized
          Quality control according to ASTM F 2212-02
          Storage
          The originally packed Collagen Cell Carrier should be stored dry and dark between +15°C and +25°C in closed packaging.
          Shelf life: 60 months
          Note
          The order information is for CCCs in R&D quality. For ordering CCCs in medical quality, please contact us directly:
      • Applications
        • Application
          Cell culture
          Application Description
          Applications in R&D and Basic Medical Research
          - Universal culture of adherent cells
          - Tissue engineering & regenerative medicine
          - Implantation and fixation of cells
          - Development of Advanced Therapy Medicinal Products (ATMPs)
          - Co-culture of cells on both sides
          - Sectioning for histologic anaylsis
          - Fluorescent imaging of adhered cells
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