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Overview
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The TCR gamma delta heterodimer of the CD3/T-cell receptor complex is clonotypic and consists of Ig-like variable and constant domains. It is expressed during thymopoiesis and on the small subpopulation of gamma delta TCR expressing T lymphocytes in the periphery. The majority of T cells present in some epithelial tissues are gamma delta+ and have limited receptor diversity. The TCR gamma delta heterodimer recognizes peptide antigen bound to MHC antigens, and subsequent signal transduction mediated by the invariant chains leads to T cell activation.
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