Anti-PAX8 antibody

Catalog Number:
STJ160014
Price:
$3,082
  • Size:
    Quantity:
    Add to Cart:
      • Overview
        • PAX-8 is a member of the paired box (PAX) family of transcription factors, which are key regulators in early development. This protein plays a role in development of thyroid follicular cells and the expression of thyroid-specific genes, with mutations in the PAX-8 gene linked to thyroid follicular carcinomas, atypical thyroid adenomas, and thyroid dysgenesis. The PAX-8 protein is expressed in simple ovarian inclusion cysts and non-ciliated mucosal cells of the fallopian tubes, but is absent from normal ovarian surface epithelial cells. PAX-8 is also not expressed in normal lung or lung carcinomas. Reports have associated PAX-8 expression with renal carcinoma, nephroblastoma, and seminoma, and have indicated PAX-8 as a useful marker for renal epithelial tumors, ovarian cancer, and for differential diagnoses in lung and neck tumors. Anti-PAX-8 can be useful in determining the primary site of invasive micropapillary carcinomas of ovary from bladder, lung, and breast, when used in adjunct with a panel of organ-specific markers such as uroplakin, mammaglobin, and TTF-1.

          Please contact us at  for specific academic pricing.

      • Properties
        • Host
          mouse
          Antibody Type
          monoclonal
          Reactivity
          human
          Clone
          IHC008
          Immunogen
          Human PAX-8 protein.
          Conjugate
          Unconjugated
          Formulation
          Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
          Storage
          Store at 2-8°C. Do not freeze.
          Regulatory Status
          RUO
          Antigen
          Paired Box Protein Pax-8 (Gene ID:7849; UniProt:Q06710)

          * For research use only

      • Applications
        • Application
          IHC (paraffin)
        • Application Dilutions
          IHC (paraffin) 1:100-1:200
    Copyright © Amerigo Scientific. All rights reserved.