Anti-MYC antibody

Catalog Number:
STJ180021
Price:
$719
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      • Overview
        • Oncogene‐encoded proteins c‐myc, N‐myc, and L‐myc function in cell proliferation, differentiation andneoplastic disease. Amplification of the c‐mycgene hasbeen found in several types of human tumors, the N‐mycgene in neuroblastomas, and the L‐mycgene in human small cell lung carcinomas. c‐myc protein is atranscription factor localized to the nucleus of the cell. Itseems to be involved in activating the transcription of growthrelatedgenes. c‐myc binds to DNA during transcription as aheterodimeric complex with Max. c‐ myc is phosphorylated invitro by p44/42 MAP kinase at Ser62 and in vivo at bothThr58 and Ser62. Mutation of Thr58 and Ser62 to Alainhibits the ability of c‐myc to activate transcription

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      • Properties
        • Host
          rabbit
          Antibody Type
          monoclonal
          Isotype
          IgG
          Reactivity
          human
          Clone
          EP121
          Immunogen
          A synthetic peptide corresponding to residuesin the N‐terminus of human c‐myc
          Conjugate
          Unconjugated
          Formulation
          Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
          Storage
          Store at 2-8°C for up to 1 year
          Regulatory Status
          RUO

          * For research use only

      • Applications
        • Application
          IHC (paraffin)
        • Application Dilutions
          IHC (paraffin) 1:50‐100
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