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Overview
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EGFR is type I receptor tyrosine kinase with sequence homology to erbB‐1, ‐2, ‐3 ‐4 or HER‐1, ‐2, ‐3 ‐4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor‐ a (TGFa), Heparin‐binding EGF (HB‐EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
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Overview