Anti-CD274 antibody

Catalog Number:
STJ160016
Price:
$1,379
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      • Overview
        • Programmed Death-Ligand 1 (PD-L1), also known as CD274 or B7 Homolog 1 (B7-H1), is a transmembrane protein involved in suppressing the immune system and rendering tumor cells resistant to CD8+ T cell-mediated lysis through binding of the Programmed Death-1 (PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumor aggressiveness and risk of death, and, in ovarian cancer, higher expression of this protein has lead to significantly poorer prognosis. PD-L1 has also been linked to systemic lupus erythematosus and cutaneous melanoma. When considered in adjunct with CD8+ tumor-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small cell lung cancer, hormone receptor negative breast cancer, and sentinel lymph node melanoma.

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      • Properties
        • Host
          rabbit
          Antibody Type
          monoclonal
          Reactivity
          human
          Clone
          IHC411
          Immunogen
          Human PD-L1 protein.
          Conjugate
          Unconjugated
          Formulation
          Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
          Storage
          Store at 2-8°C. Do not freeze.
          Regulatory Status
          RUO
          Antigen
          Programmed Cell Death 1 Ligand 1; Pd-L1; Pdcd1 Ligand 1; Programmed Death Ligand 1; Hpd-L1; B7 Homolog 1; B7-H1; Cd Antigen Cd274 (Gene ID:29126; UniProt:Q9NZQ7)

          * For research use only

      • Applications
        • Application
          IHC (paraffin)
        • Application Dilutions
          IHC (paraffin) 1:100-1:200
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