Anti-BAP1 antibody

Catalog Number:
STJ180014
Price:
$642
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      • Overview
        • BAP1 (BRCA1‐Associated Protein 1) was initially identified as a protein thatbinds to BRCA1. BAP1 is a tumor suppressor that is believed to mediate its effects through chromatin modulation, transcriptional regulation, and possibly via the ubiquitin‐proteasome system and the DNA damage response pathway. Germline mutations of BAP1 confer increased susceptibility for the development of several tumors, including uveal melanoma, epithelioid atypical Spitz tumors, cutaneous melanoma, and mesothelioma. Somatic BAP1 mutations are seen in cutaneous melanocytic tumors (epithelioid atypical Spitz tumors and melanoma), uveal melanoma, mesothelioma, clear cell renalcell carcinoma, and other tumors. BAP1 immunohistochemistry is particularly useful in differentiating malignant mesothelioma (nuclear negative) vs. reactive mesothelial proliferation (nuclear positiv

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      • Properties
        • Host
          mouse
          Antibody Type
          monoclonal
          Isotype
          IgG1 kappa
          Reactivity
          human
          Clone
          C4
          Immunogen
          Synthetic peptide against 430‐729 of human BAP1
          Conjugate
          Unconjugated
          Formulation
          Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
          Storage
          Store at 2-8°C for up to 1 year
          Regulatory Status
          RUO
          Antigen
          E3 Ubiquitin-Protein Ligase Ring2; Huntingtin-Interacting Protein 2-Interacting Protein 3; Hip2-Interacting Protein 3; Protein Ding; Ring Finger Protein 1b; Ring1b; Ring Finger Protein 2; Ring Finger Protein Bap-1; Ring-Type E3 Ubiquitin Transferase Ring2 (Gene ID:6045; UniProt:Q99496)

          * For research use only

      • Applications
        • Application
          IHC (paraffin)
        • Application Dilutions
          IHC (paraffin) 1:100
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